血清素能激动剂丁螺环酮和舒马曲坦对人体垂体后叶激素低血糖反应的不同影响。

Different effects of the serotonergic agonists buspirone and sumatriptan on the posterior pituitary hormonal responses to hypoglycemia in humans.

作者信息

Chiodera P, Volpi R, Capretti L, Caffarri G, Magotti M G, Coiro V

机构信息

Cattedra di Endocrinologia, Università di Parma, Italy.

出版信息

Neuropeptides. 1996 Apr;30(2):187-92. doi: 10.1016/s0143-4179(96)90086-4.

DOI:10.1016/s0143-4179(96)90086-4

PMID:8771561

Abstract

The responses of serum oxytocin (OT) and vasopressin (AVP) to the serotonergic HT1A agonist buspirone (15 mg p.o.) or the HTD1 agonist sumatriptan (6 mg injected subcutaneously) were evaluated in 7 normal men either in basal conditions or during an insulin (0.15 iu/kg as an i.v. bolus) tolerance test (ITT). Neither buspirone nor sumatriptan administration modified the basal secretion of AVP and OT. Stimulation of 5HT-1D receptors with sumatriptan was unable to change neither AVP nor OT response to insulin-induced hypoglycemia. On the other hand, the pretreatment with the 5HT1A agonist buspirone significantly enhanced the OT response during hypoglycemia, without modifying the AVP rise. The results of this study suggest that serotonergic 5HT1A receptors may interact with hypoglycemia in the stimulation of OT, but not AVP secretion.

摘要

在7名正常男性中，于基础状态或胰岛素（0.15 iu/kg静脉推注）耐量试验（ITT）期间，评估血清催产素（OT）和血管加压素（AVP）对5-羟色胺能HT1A激动剂丁螺环酮（口服15 mg）或5-HT1D激动剂舒马曲坦（皮下注射6 mg）的反应。给予丁螺环酮或舒马曲坦均未改变AVP和OT的基础分泌。用舒马曲坦刺激5HT-1D受体既不能改变AVP也不能改变OT对胰岛素诱导的低血糖的反应。另一方面，用5HT1A激动剂丁螺环酮预处理可显著增强低血糖期间的OT反应，而不改变AVP的升高。本研究结果提示，5-羟色胺能5HT1A受体在刺激OT分泌而非AVP分泌方面可能与低血糖相互作用。