Department of Internal Medicine and Biochemical Sciences, University of Parma, Parma, Italy.
Neuropeptides. 2010 Feb;44(1):53-6. doi: 10.1016/j.npep.2009.10.004. Epub 2009 Nov 14.
The present study was undertaken in order to establish the possible involvement of serotonergic receptors in the control of physical exercise-stimulated vasopressin secretion. Twenty-one healthy men (divided in three groups of seven) underwent bicycle-ergometer tests until exhaustion: exercise control test (n=21), exercise plus ondansetron, selective 5-HT3 antagonist (n=7), exercise plus buspirone, selective 5-HT1A receptor agonist (n=7), exercise plus sumatriptan, selective 5-HT1D receptor agonist (n=7). AVP levels, physiological and biochemical variables were measured and compared during tests. Results showed that exercise-induced AVP rise did not change after the administration of buspirone and sumatriptan. In contrast, the administration of ondansetron significantly reduced physical exercise-induced AVP rise. Mean peak levels during physical exercise were 4.9 times higher than basal values in the control test and 2.6 times higher than basal values in the ondansetron plus exercise test. These data demonstrate that 5-HT3 serotonergic receptors at least partially mediate the AVP response to physical exercise. On the other hand, 5-HT1A and 5-HT1D serotonergic receptors do not appear to be involved in the control of AVP secretion during exercise.
本研究旨在确定 5-羟色胺能受体在体力活动刺激抗利尿激素分泌的控制中可能发挥的作用。21 名健康男性（分为三组，每组 7 人）进行了自行车测力计测试直至力竭：运动对照测试（n=21）、运动加昂丹司琼（n=7）、5-羟色胺 3 受体选择性拮抗剂、运动加丁螺环酮（n=7）、5-羟色胺 1A 受体选择性激动剂、运动加舒马曲坦（n=7）、5-羟色胺 1D 受体选择性激动剂。在测试过程中测量和比较了 AVP 水平、生理和生化变量。结果表明，丁螺环酮和舒马曲坦给药后，运动诱导的 AVP 升高没有改变。相比之下，昂丹司琼的给药显著降低了体力活动诱导的 AVP 升高。在对照试验中，体力活动期间的平均峰值水平比基础值高 4.9 倍，在昂丹司琼加运动试验中比基础值高 2.6 倍。这些数据表明，5-羟色胺 3 能受体至少部分介导了 AVP 对体力活动的反应。另一方面，5-羟色胺 1A 和 5-羟色胺 1D 能受体似乎不参与运动期间 AVP 分泌的控制。
