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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Head E, Hartley J, Kameka A M, Mehta R, Ivy G O, Ruehl W W, Milgram N W

University of Toronto, Division of Life Sciences, Scarborough, Ontario, Canada.

Prog Neuropsychopharmacol Biol Psychiatry. 1996 Apr;20(3):515-30. doi: 10.1016/0278-5846(96)00014-0.

Young and aged dogs were tested on a spatial memory task using a delayed non matching to sample technique. Dogs were tested with 20, 70 and 110 second delay intervals. Animals were pretrained to a stable level of performance prior to treatment. 2. During treatment periods, dogs were orally administered a placebo or I-deprenyl in doses of 0.5 and 1.0 mg/kg in a repeated measures design. 3. Young dogs did not show any significant effects of I-deprenyl, however the sample size was limited. 4. L-deprenyl administration improved spatial memory in aged dogs. 5. The optimal dose or length of treatment time of I-deprenyl varied among individual dogs.

采用延迟非匹配样本技术，对幼犬和老龄犬进行空间记忆任务测试。犬只接受了20秒、70秒和110秒的延迟间隔测试。在治疗前，动物被预训练至稳定的表现水平。2. 在治疗期间，采用重复测量设计，给犬只口服安慰剂或剂量为0.5毫克/千克和1.0毫克/千克的左旋司来吉兰。3. 幼犬未表现出左旋司来吉兰的任何显著效果，然而样本量有限。4. 给予老龄犬左旋司来吉兰可改善其空间记忆。5. 左旋司来吉兰的最佳剂量或治疗时间长度在不同犬只中有所不同。

Head E, Hartley J, Kameka A M, Mehta R, Ivy G O, Ruehl W W, Milgram N W

University of Toronto, Division of Life Sciences, Scarborough, Ontario, Canada.

Prog Neuropsychopharmacol Biol Psychiatry. 1996 Apr;20(3):515-30. doi: 10.1016/0278-5846(96)00014-0.

Young and aged dogs were tested on a spatial memory task using a delayed non matching to sample technique. Dogs were tested with 20, 70 and 110 second delay intervals. Animals were pretrained to a stable level of performance prior to treatment. 2. During treatment periods, dogs were orally administered a placebo or I-deprenyl in doses of 0.5 and 1.0 mg/kg in a repeated measures design. 3. Young dogs did not show any significant effects of I-deprenyl, however the sample size was limited. 4. L-deprenyl administration improved spatial memory in aged dogs. 5. The optimal dose or length of treatment time of I-deprenyl varied among individual dogs.

采用延迟非匹配样本技术，对幼犬和老龄犬进行空间记忆任务测试。犬只接受了20秒、70秒和110秒的延迟间隔测试。在治疗前，动物被预训练至稳定的表现水平。2. 在治疗期间，采用重复测量设计，给犬只口服安慰剂或剂量为0.5毫克/千克和1.0毫克/千克的左旋司来吉兰。3. 幼犬未表现出左旋司来吉兰的任何显著效果，然而样本量有限。4. 给予老龄犬左旋司来吉兰可改善其空间记忆。5. 左旋司来吉兰的最佳剂量或治疗时间长度在不同犬只中有所不同。