Carter C S, Robertson L C, Nordahl T E, Chaderjian M, Oshora-Celaya L
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213-2593, USA. cscarter+@pitt.edu
Psychiatry Res. 1996 May 17;62(2):111-9. doi: 10.1016/0165-1781(96)02849-1.
Increasing evidence suggests the presence of a lateralizing attentional deficit in schizophrenia. In the present study, 23 unmedicated patients with schizophrenia (mean age = 32.1 years) and 14 age- and sex-matched normal subjects were studied with the Global/Local Task to provide converging evidence for the presence of a left-hemisphere-associated attentional deficit in schizophrenia. This task is sensitive to the integrity of mechanisms involved in discriminating local and global elements of stimuli. Previous research has linked the discrimination of local targets to left hemispheric processes and the discrimination of global targets to right hemispheric processes. As predicted, patients were impaired in the detection of local level targets, consistent with a left hemispheric deficit. The degree of impairment correlated with the patient's level of auditory hallucinations. These results are consistent with previous studies showing an asymmetrical attentional deficit in schizophrenia and left hemispheric dysfunction. The correlation between this deficit and auditory hallucinations is consistent with a hypothesized relationship between this symptom in schizophrenia and left temporal pathology.
越来越多的证据表明精神分裂症存在偏侧化注意缺陷。在本研究中，对23名未服药的精神分裂症患者（平均年龄 = 32.1岁）和14名年龄及性别匹配的正常受试者进行了整体/局部任务研究，以提供关于精神分裂症存在与左半球相关的注意缺陷的聚合证据。该任务对辨别刺激的局部和整体元素所涉及的机制完整性敏感。先前的研究已将局部目标的辨别与左半球过程联系起来，将整体目标的辨别与右半球过程联系起来。正如所预测的，患者在检测局部水平目标方面受损，这与左半球缺陷一致。受损程度与患者的幻听水平相关。这些结果与先前的研究一致，表明精神分裂症存在不对称注意缺陷和左半球功能障碍。这种缺陷与幻听之间的相关性与精神分裂症中该症状与左颞叶病变之间的假设关系一致。
