对间氯苯哌嗪（m-CPP）的激素反应不会因急性m-CPP预处理而减弱。

Hormonal responses to meta-chlorophenylpiperazine (m-CPP) are undiminished by acute m-CPP pretreatment.

作者信息

Coccaro E F, Kavoussi R J, Trestman R L, Gabriel S M, Cooper T B, Siever L J

机构信息

Department of Psychiatry, Medical College of Pennsylvania, Philadelphia, USA.

出版信息

Psychiatry Res. 1996 May 17;62(2):139-45. doi: 10.1016/0165-1781(96)02826-0.

DOI:10.1016/0165-1781(96)02826-0

PMID:8771611

Abstract

Two challenges with meta-chlorophenylpiperazine (m-CPP, 0.5 mg/kg, p.o.) were performed in healthy volunteers to test the short-term stability of hormonal responses. Challenges were performed in an identical fashion and were conducted on sequential days. Circulating m-CPP plasma levels, as well as prolactin and cortisol responses to m-CPP, were correspondingly similar in magnitude on the 2 days. These data suggest that both prolactin and cortisol responses to single oral administrations of m-CPP are stable over at least a 24-h period.

摘要

在健康志愿者中进行了两次间氯苯哌嗪（m-CPP，0.5毫克/千克，口服）激发试验，以测试激素反应的短期稳定性。激发试验以相同方式进行，且在连续的日子里开展。在这两天中，循环中的m-CPP血浆水平以及对m-CPP的催乳素和皮质醇反应在幅度上相应地相似。这些数据表明，单次口服m-CPP后催乳素和皮质醇的反应在至少24小时的时间段内是稳定的。