Bessmel'tsev S S, Khorshev S K, Abdulkadyrov K M, Shilova E R
Ter Arkh. 1996;68(2):56-9.
Blood coagulation and rheology were studied with regard to severity of hemorrhagic syndrome and neurological complications in 44 patients with aplastic anemia (AA). Most of these patients appeared to have DIC-syndrome with serious rheological shifts. The patients suffered from hemorrhagic diathesis, nasal and gingival hemorrhages. With AA progression the severity and frequency of hemorrhagic complications increased. Neurological examination revealed in 9 of 12 AA patients organic affections of the nervous system with EEG evidence of bioelectrical shifts. In some patients neurological complications were registered prior to hemorrhagic. Therefore, to diagnose hemorrhagic complications in AA patients it is necessary to assess in details their hemocoagulation, blood rheology and neurological status.
对44例再生障碍性贫血（AA）患者的出血综合征严重程度和神经并发症进行了血液凝固和流变学研究。这些患者中的大多数似乎患有弥散性血管内凝血（DIC）综合征，并伴有严重的流变学改变。患者有出血素质，出现鼻出血和牙龈出血。随着再生障碍性贫血病情进展，出血并发症的严重程度和发生率增加。神经学检查发现，12例再生障碍性贫血患者中有9例存在神经系统器质性病变，脑电图有生物电改变的证据。在一些患者中，神经并发症在出血之前就已出现。因此，要诊断再生障碍性贫血患者的出血并发症，有必要详细评估他们的血液凝固、血液流变学和神经状态。
