Pronin A V, Belyĭ Iu F, Bdeui I, Deeva A V, Tartakovskiĭ I S
Zh Mikrobiol Epidemiol Immunobiol. 1996 May-Jun(3):53-6.
Two protein antigens with molecular weights of 58 kD (antigen Lm58) and 79/39 kD (antigen Lm79/ 39) were isolated from Listeria monocytogenes cell wall. Only Lm79/39 was shown to protect mice from L. monocytogenes infection, increasing their LD50 and survival time. The protective activity of Lm79/39 correlated (r = 0.64) with its mitogenic properties and its capacity for activating the production of interleukin-1- and interleukin-2-like factors. More over Lm79/ 39 induced more strong than Lm58 specific lymphocyte proliferation. The two antigens had practically no difference in their capacity for cytotoxic cell activation. The protective activity of Lm79/39 is probably linked with its immunomodulating properties, which opens a perspective for its use as a component of an antilisteriosis vaccine.
从单核细胞增生李斯特菌细胞壁中分离出两种分子量分别为58kD（抗原Lm58）和79/39kD（抗原Lm79/39）的蛋白质抗原。仅Lm79/39被证明可保护小鼠免受单核细胞增生李斯特菌感染，提高其半数致死量（LD50）并延长存活时间。Lm79/39的保护活性与其促有丝分裂特性及其激活白细胞介素-1和白细胞介素-2样因子产生的能力相关（r = 0.64）。此外，Lm79/39比Lm58诱导更强的特异性淋巴细胞增殖。这两种抗原在激活细胞毒性细胞的能力方面几乎没有差异。Lm79/39的保护活性可能与其免疫调节特性有关，这为其作为抗李斯特菌病疫苗的成分使用开辟了前景。
