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蛋白质磷酸化的更多靶向作用：通过定位赋予特异性

More on target with protein phosphorylation: conferring specificity by location.

作者信息

Faux M C, Scott J D

机构信息

Vollum Institute L474, Oregon Health Sciences University, Portland 97020-3098, USA.

出版信息

Trends Biochem Sci. 1996 Aug;21(8):312-5.

PMID:8772386
Abstract

One important regulatory mechanism in the control of phosphorylation events is the subcellular location of phosphatases of kinases. Several serine/threonine phosphatases and kinases have now been shown to be associated with targeting subunits; these contribute to the organization and specificity of signal transduction pathways by favoring the accessibility of their enzymes to certain substrates.

摘要

控制磷酸化事件的一个重要调节机制是激酶磷酸酶的亚细胞定位。现在已经证明，几种丝氨酸/苏氨酸磷酸酶和激酶与靶向亚基相关联；这些通过促进其酶对某些底物的可及性，有助于信号转导通路的组织和特异性。

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