Kimura Shintaro, Lok Josephine, Gelman Irwin H, Lo Eng H, Arai Ken
Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Life Science Research Center, Gifu University, Gifu, Japan.
J Clin Neurol. 2023 Jul;19(4):329-337. doi: 10.3988/jcn.2023.0095.
A-kinase anchoring protein (AKAP) 12 is a scaffolding protein that anchors various signaling proteins to the plasma membrane. These signaling proteins include protein kinase A, protein kinase C, protein phosphatase 2B, Src-family kinases, cyclins, and calmodulin, which regulate their respective signaling pathways. AKAP12 expression is observed in the neurons, astrocytes, endothelial cells, pericytes, and oligodendrocytes of the central nervous system (CNS). Its physiological roles include promoting the development of the blood-brain barrier, maintaining white-matter homeostasis, and even regulating complex cognitive functions such as long-term memory formation. Under pathological conditions, dysregulation of AKAP12 expression levels may be involved in the pathology of neurological diseases such as ischemic brain injury and Alzheimer's disease. This minireview aimed to summarize the current literature on the role of AKAP12 in the CNS.
A激酶锚定蛋白（AKAP）12是一种支架蛋白，可将各种信号蛋白锚定到质膜上。这些信号蛋白包括蛋白激酶A、蛋白激酶C、蛋白磷酸酶2B、Src家族激酶、细胞周期蛋白和钙调蛋白，它们调节各自的信号通路。在中枢神经系统（CNS）的神经元、星形胶质细胞、内皮细胞、周细胞和少突胶质细胞中可观察到AKAP12的表达。其生理作用包括促进血脑屏障的发育、维持白质稳态，甚至调节诸如长期记忆形成等复杂的认知功能。在病理条件下，AKAP12表达水平的失调可能与缺血性脑损伤和阿尔茨海默病等神经疾病的病理过程有关。本综述旨在总结当前关于AKAP12在中枢神经系统中作用的文献。
