Hutchinson G A, Nehall J E, Simeon D T
Maudsley Hospital, London, UK.
West Indian Med J. 1996 Jun;45(2):48-50.
The symptoms of Systemic Lupus Erythematosus (SLE) may include altered mental function. The present study sought to determine whether the psychiatric disorders are due to the disease itself or to the stress of having a chronic disease. Forty-five SLE patients attending outpatient clinics at the Port-of-Spain General Hospital in Trinidad were compared with two control groups: patients with chronic debilitating diseases similar to SLE in terms of chronicity and treatment (n = 44) and non-diseased individuals (n = 48). The Structured Clinical Interview for DSM III-R was used to identify psychiatric disorders. Both the SLE and the chronic illness groups had more psychiatric illness (44% and 39%, respectively) when compared with the non-diseased controls (2%) (p < 0.001). Major depression was the most common diagnosis among both diseased groups. However, psychotic illnesses (schizophrenic-type psychosis and bipolar disorders) were more prevalent in the SLE group (11.1% vs 0%, p = 0.02). These results indicate that major depression in SLE may be related more to the effects of a chronic illness than to SLE itself. However, the occurrence of psychotic symptoms may be related to SLE disease and needs further study.
系统性红斑狼疮（SLE）的症状可能包括精神功能改变。本研究旨在确定精神障碍是由疾病本身还是由患慢性病的压力所致。将在特立尼达西班牙港总医院门诊就诊的45名SLE患者与两个对照组进行比较：患有与SLE在慢性病程度和治疗方面相似的慢性衰弱性疾病的患者（n = 44）和无病个体（n = 48）。使用针对《精神疾病诊断与统计手册》第三版修订本（DSM III-R）的结构化临床访谈来识别精神障碍。与无病对照组（2%）相比，SLE组和慢性病组的精神疾病患者更多（分别为44%和39%）（p < 0.001）。重度抑郁症是两个患病组中最常见的诊断。然而，精神病性疾病（精神分裂症型精神病和双相情感障碍）在SLE组中更为普遍（11.1%对0%，p = 0.02）。这些结果表明，SLE中的重度抑郁症可能更多地与慢性病的影响有关，而非SLE本身。然而，精神病性症状的出现可能与SLE疾病有关，需要进一步研究。
