Jubelirer S J
Cancer Care Center of Southern West Virginia, Charleston Area Medical Center, USA.
W V Med J. 1996 Jul-Aug;92(4):186-90.
This article reviews the cases of 138 patients at the Charleston Area Medical Center who were treated for glioblastoma multiforme (astrocytoma Grade IV) between 1966-1987. Data was obtained from the hospital's tumor registry, inpatient/outpatient records, pathology reports, as well as radiotherapy records. The median survival rate for all patients was 7 months (range 1-36 months). The median survival of the patients who underwent complete resection and received radiotherapy was 12 months, while the median survival rate was four months for patients who had complete resection but did not undergo radiotherapy. In addition, the median survival of the patients who underwent incomplete resection with radiotherapy was 10 months compared to a survival rate of 3 months of those who did not undergo radiotherapy after incomplete resection. Radiotherapy was the most significant predictor of survival with age being the major factor. Despite the clinical advancements made in the past 10-15 years, no impact has yet been achieved on the natural history of glioblastoma multiforme.
本文回顾了1966年至1987年间在查尔斯顿地区医疗中心接受多形性胶质母细胞瘤（IV级星形细胞瘤）治疗的138例患者的病例。数据来自医院的肿瘤登记处、住院/门诊记录、病理报告以及放疗记录。所有患者的中位生存期为7个月（范围为1至36个月）。接受完全切除并接受放疗的患者的中位生存期为12个月，而接受了完全切除但未接受放疗的患者的中位生存期为4个月。此外，接受不完全切除并接受放疗的患者的中位生存期为10个月，相比之下，不完全切除后未接受放疗的患者的生存期为3个月。放疗是生存的最重要预测因素，年龄是主要因素。尽管在过去10至15年中取得了临床进展，但尚未对多形性胶质母细胞瘤的自然病程产生影响。
