Closa D, Bardají M, Hotter G, Prats N, Gelpí E, Fernández-Cruz L, Roselló-Catafau J
Department of Medical Bioanalysis, Centro de Investigación y Desarrollo, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain.
Am J Physiol. 1996 Jan;270(1 Pt 1):G6-13. doi: 10.1152/ajpgi.1996.270.1.G6.
The role of liver in the respiratory dysfunction associated with acute pancreatitis has been evaluated. For this purpose, an experimental necrohemorrhagic pancreatitis was induced in rats by intraductal administration of 3.5% sodium taurocholate. Additionally, a portocaval shunt was performed before induction of acute pancreatitis to prevent the initial passage through the liver of substances released by the pancreas. Twelve hours after the induction of pancreatitis, increases in lung prostacyclin and thromboxane B2 synthesis, decreased lung superoxide dismutase activity, and increases in plasma phospholipase A2 activity were found. In addition, inflammatory injury was evidenced in lung by histopathological analysis. The portocaval shunt was able to prevent the metabolic changes and ameliorate the inflammatory process in the lung, suggesting that the liver plays an active role in the systemic inflammatory response to acute pancreatitis.
肝脏在急性胰腺炎相关呼吸功能障碍中的作用已得到评估。为此，通过导管内注射3.5%牛磺胆酸钠在大鼠中诱发实验性坏死性出血性胰腺炎。此外，在诱发急性胰腺炎之前进行门腔分流术，以防止胰腺释放的物质最初通过肝脏。胰腺炎诱发12小时后，发现肺前列环素和血栓素B2合成增加、肺超氧化物歧化酶活性降低以及血浆磷脂酶A2活性增加。此外，组织病理学分析证明肺存在炎症损伤。门腔分流术能够预防代谢变化并改善肺部的炎症过程，这表明肝脏在对急性胰腺炎的全身炎症反应中发挥积极作用。
