Shukla R, Garg R K, Nag D, Ahuja R C
Department of Neurology, King George's Medical College, Lucknow.
J Assoc Physicians India. 1995 Nov;43(11):770-2.
Nifedipine was evaluated in the prophylaxis of 28 patients each of migraine and tension headache using a double blind cross over design with random allocation to drug or placebo group. The duration of the trial was 3 months with a 2 week run-in period and 2 week wash-oat period separating two treatment periods of 4 weeks each. A satisfactory response was obtained in 71.4% of migraineurs (p < 0.001) and 28.6% of patients with tension headache (p = N.S). Minor side effects were observed in 5 patients. Nifedipine is a useful agent for the management of migraine as it reduces frequency and severity of pain but the drug cannot be recommended for tension headache.
采用双盲交叉设计，将28例偏头痛患者和28例紧张性头痛患者随机分为药物组或安慰剂组，对硝苯地平进行预防偏头痛和紧张性头痛的评估。试验为期3个月，有2周的导入期和2周的洗脱期，将两个为期4周的治疗期分开。71.4%的偏头痛患者（p<0.001）和28.6%的紧张性头痛患者（p=无统计学意义）获得了满意的反应。5例患者出现轻微副作用。硝苯地平是治疗偏头痛的有效药物，因为它能降低疼痛的频率和严重程度，但该药物不推荐用于治疗紧张性头痛。
