Shukla R, Nag D, Ahuja R C
Department of Neurology, King George's Medical College, Lucknow.
J Assoc Physicians India. 1996 Sep;44(9):641-4.
Alprazolam was evaluated in the treatment of 62 patients of chronic tension type headache using a double blind cross over design with random allocation to drug or placebo. The duration of the trial was 4 months with a 2 week run in period and 2 week washout period separating two treatment periods of 4 weeks each. The patients were followed up for 4 weeks at the completion of the trial. 48 patients completed the trial. There was no significant difference in the overall response rate based in terms of percentage reduction in headache frequency per week, however a significant decrease in headache index was observed during treatment with alprazolam as compared to placebo (P < 0.05). The mean analgesic intake per week was also significantly lower during treatment with alprazolam as compared to the run in period. Side effects were seen in 16.67% patients. In none of the patients was it significant enough to require withdrawal from the study.
采用双盲交叉设计，将62例慢性紧张型头痛患者随机分为药物组或安慰剂组，对阿普唑仑治疗慢性紧张型头痛的效果进行评估。试验为期4个月，有2周的导入期和2周的洗脱期，将两个为期4周的治疗期分开。在试验结束时对患者进行了4周的随访。48例患者完成了试验。基于每周头痛频率降低的百分比，总体缓解率无显著差异，然而与安慰剂相比，在阿普唑仑治疗期间观察到头痛指数显著降低（P<0.05）。与导入期相比，阿普唑仑治疗期间每周的平均镇痛药摄入量也显著降低。16.67%的患者出现了副作用。在所有患者中，副作用均未严重到需要退出研究的程度。
