Helmeste D, Tang S W, Fang H, Li M
Department of Psychiatry and Human Behavior, University of California at Irvine 92717, USA.
Eur J Pharmacol. 1996 Apr 22;301(1-3):R1-3. doi: 10.1016/0014-2999(96)00078-7.
Binding of [3H]nemonapride and [3H]raclopride was examined in the brain areas of three species (rat, cow and human). The results indicated that [3H]nemonapride binding is inhibited by selective sigma receptor ligands in frontal cortex, striatum and cerebellum. Only the striatum showed significant dopaminergic sites as defined by sulpiride. Use of the subtraction method of [3H]nemonapride minus [3H]raclopride binding as a measure of D4 dopamine receptor binding may, therefore, also include a sigma receptor component.
在三种物种（大鼠、牛和人类）的脑区检测了[3H]奈莫必利和[3H]雷氯必利的结合情况。结果表明，[3H]奈莫必利的结合在额叶皮质、纹状体和小脑中受到选择性σ受体配体的抑制。只有纹状体显示出由舒必利定义的显著多巴胺能位点。因此，使用[3H]奈莫必利减去[3H]雷氯必利结合的减法方法作为D4多巴胺受体结合的测量方法，可能也包括一个σ受体成分。
