Himi T, Ikeda M, Sato I, Yuasa T, Murota S
Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan.
Brain Res. 1996 Apr 29;718(1-2):189-92. doi: 10.1016/0006-8993(96)00017-0.
To study the effects of chemical injury on the cerebellar nitric oxide synthase (NOS), we administered methylmercury chloride subcutaneously to mice, 10 mg/kg/day for 9 days. In the methylmercury-treated cerebellum. Purkinje cells were positive both for NADPH-diaphorase and for neuronal NOS. Calcium-dependent NOS activity was increased to 160% of the controls. The present study suggests the ability of Purkinje cells to produce NO through the expression of neuronal NOS.
