加的夫产后情绪与激素研究。III. 产后5至6周的产后抑郁症及其在围产期的激素关联
Cardiff puerperal mood and hormone study. III. Postnatal depression at 5 to 6 weeks postpartum, and its hormonal correlates across the peripartum period.
作者信息
Harris B, Lovett L, Smith J, Read G, Walker R, Newcombe R
机构信息
Department of Psychiatry, University of Wales College of Medicine, Whitchurch Hospital, Cardiff.
出版信息
Br J Psychiatry. 1996 Jun;168(6):739-44. doi: 10.1192/bjp.168.6.739.
BACKGROUND
We assessed associations of mood at 5-6 weeks postpartum with peripartum saliva cortisol and progesterone profiles.
METHOD
A prospective study involved 120 primiparous women free of major marital, socioeconomic and health problems, who collected saliva twice daily from 2 weeks before delivery to day 35 postpartum. This allowed intensive characterisation of cortisol and progesterone profiles. At the conclusion of the study, mood was assessed according to standard criteria.
RESULTS
Seven women developed major depression according to DSM-III-R criteria. No associations emerged between progesterone and mood at 5 to 6 weeks. Lower levels of evening cortisol in the immediate peripartum period, were associated with postnatal depression.
CONCLUSION
The study provides no support for the treatment strategy of progesterone augmentation following delivery, as a prophylactic against postnatal depression. The HPA axis and its associations with postnatal mood warrants further investigation.
背景
我们评估了产后5 - 6周时的情绪与围产期唾液皮质醇和孕酮水平之间的关联。
方法
一项前瞻性研究纳入了120名初产妇，她们没有重大婚姻、社会经济和健康问题，从分娩前2周至产后35天每天收集两次唾液。这使得能够对皮质醇和孕酮水平进行密集特征分析。在研究结束时，根据标准标准评估情绪。
结果
根据《精神疾病诊断与统计手册》第三版修订版（DSM - III - R）标准，有7名女性患上了重度抑郁症。在产后5至6周时，孕酮与情绪之间未发现关联。围产期即刻的夜间皮质醇水平较低与产后抑郁症有关。
结论
该研究不支持产后增加孕酮作为预防产后抑郁症的治疗策略。下丘脑 - 垂体 - 肾上腺（HPA）轴及其与产后情绪的关联值得进一步研究。
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