Fernández B E, Domińguez A E, Vidal N A
Rev Esp Fisiol. 1977 Jun;33(2):91-5.
The urinary excretion of the norepinephrine, epinephrine and the norepinephrine/epinephrine ratio and its modifications by the ovariectomy, adrenalectomy, hypophysectomy and the administration of sexual hormones and gonadotrophins were studied in female Wistar rats. The ovariectomy increased epinephrine excretion and decreased the studied ratio. The adrenalectomy increased norepinephrine and the ratio levels and diminshed epinephrine excretion. Norepinephrine and norepinephrine/epinephrine ratio elimination increased in the ovariectomized and adrenalectomized rats. The sexual hormones did not alter catecholamine levels in the ovariectomized and adrenalectomized animals and were not effective to restore the control levels. The norepinephrine/epinephrine ratio reached a maximum under progesterone effects. Both urinary catecholamines rose in ovariectomized and hypophysectomized animals. The chorionic and the equine gonadotrophins did not restore the control levels, but they had a tendency to do it. The results showed the existence of a close interelationship between the sympathetic system and the sexual hormones and gonadrotrophins function, that could be related to regulatory mechanisms of the hypophyseal gonadotrophins secretion.
在雌性Wistar大鼠中,研究了去甲肾上腺素、肾上腺素的尿排泄量、去甲肾上腺素/肾上腺素比值及其受卵巢切除术、肾上腺切除术、垂体切除术以及性激素和促性腺激素给药的影响。卵巢切除术增加了肾上腺素排泄并降低了所研究的比值。肾上腺切除术增加了去甲肾上腺素和该比值水平,并减少了肾上腺素排泄。去卵巢和肾上腺切除的大鼠中去甲肾上腺素和去甲肾上腺素/肾上腺素比值的消除增加。性激素未改变去卵巢和肾上腺切除动物中的儿茶酚胺水平,且无法有效恢复对照水平。去甲肾上腺素/肾上腺素比值在孕酮作用下达到最大值。在去卵巢和垂体切除的动物中,两种尿儿茶酚胺均升高。绒毛膜促性腺激素和马促性腺激素未恢复对照水平,但有恢复的趋势。结果表明交感神经系统与性激素和促性腺激素功能之间存在密切的相互关系,这可能与垂体促性腺激素分泌的调节机制有关。