Hessman Y, Rentzhog L, Ekbohm G
Acta Chir Scand. 1976;142(4):291-5.
The urinary excretions of adrenaline and noradrenaline were determined before and after a moderate thermal trauma in rats with intact adrenal glands, after adrenal demedullation and after adrenalectomy with grafting of adrenal cortical tissue. The basal excretions of adrenaline were 0.28 mug, 0.06 mug and 0.04 mug/24 h/rat, respectively. In rats with intact adrenal glands the adrenaline excretion was greatly increased already in the first 24 hours after the burn. In both the demedullated and adrenalectomized rats only a very slight increase of the adrenaline excretion was noted, but this may indicate a slight reaction of the extramedullary chromaffin tissue to the trauma. The basal excretion of noradrenaline was not affected either by demedullation or adrenalectomy, indicating that it consisted mainly in noradrenaline released from peripheral sympathetic nerve endings. From the second day after the burn there was an increase in the noradrenaline excretion, of equal magnitude in all experimental groups, indicating an increased liberation of peripheral adrenergic transmittor substances.
分别测定了肾上腺完整的大鼠、肾上腺髓质切除大鼠以及肾上腺切除并移植肾上腺皮质组织的大鼠在中度热创伤前后肾上腺素和去甲肾上腺素的尿排泄量。肾上腺素的基础排泄量分别为0.28微克、0.06微克和0.04微克/24小时/大鼠。肾上腺完整的大鼠在烧伤后的头24小时内，肾上腺素排泄量就大幅增加。在髓质切除和肾上腺切除的大鼠中，仅观察到肾上腺素排泄量有非常轻微的增加，但这可能表明髓外嗜铬组织对创伤有轻微反应。去甲肾上腺素的基础排泄量不受髓质切除或肾上腺切除的影响，这表明它主要由外周交感神经末梢释放的去甲肾上腺素组成。烧伤后第二天起，所有实验组的去甲肾上腺素排泄量均增加，且增加幅度相同，这表明外周肾上腺素能递质的释放增加。
