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苯乙烯和丙烯腈可导致多种啮齿动物肝脏中非蛋白质巯基含量降低。

Styrene and acrylonitrile induced depression of hepatic nonprotein sulfhydryl content in various rodent species.

作者信息

Vainio H, Mäkinen A

出版信息

Res Commun Chem Pathol Pharmacol. 1977 May;17(1):115-24.

PMID:877398
Abstract

Adult female mice, male rats, female hamsters and male guinea pigs received various doses of styrene (150-1000 mg/kg of body weight) and acrylonitrile (20-80 mg/kg of body weight) intraperitoneally. Both styrene and acrylonitrile caused a depression of the hepatic nonprotein sulfhydryl content. Mouse was the most vulnerable and rat the most resistant species to the effect of both of these two important plastic monomers.

摘要

成年雌性小鼠、雄性大鼠、雌性仓鼠和雄性豚鼠经腹腔注射接受了不同剂量的苯乙烯(150 - 1000毫克/千克体重)和丙烯腈(20 - 80毫克/千克体重)。苯乙烯和丙烯腈均导致肝脏非蛋白质巯基含量降低。在这两种重要的塑料单体的作用下,小鼠是最敏感的物种,而大鼠是最具抗性的物种。

相似文献

1
Styrene and acrylonitrile induced depression of hepatic nonprotein sulfhydryl content in various rodent species.苯乙烯和丙烯腈可导致多种啮齿动物肝脏中非蛋白质巯基含量降低。
Res Commun Chem Pathol Pharmacol. 1977 May;17(1):115-24.
2
Effects of acrylonitrile on tissue glutathione concentrations in rat, mouse, and hamster.
Res Commun Chem Pathol Pharmacol. 1984 Mar;43(3):507-10.
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Pathological and hepatic ultrastructural effects of a single dose of perfluoro-n-decanoic acid in the rat, hamster, mouse, and guinea pig.单剂量全氟癸酸对大鼠、仓鼠、小鼠和豚鼠的病理及肝脏超微结构影响
Fundam Appl Toxicol. 1987 Oct;9(3):522-40.
4
[Relation between the quantity of sulfhydryl groups and the level of antioxidant activity of organ lipids in individual animals of different species].[不同物种个体动物中巯基数量与器官脂质抗氧化活性水平之间的关系]
Radiobiologiia. 1982 May-Jun;22(3):301-6.
5
NTP technical report on the toxicity studies of methacrylonitrile (CAS No. 126-98-7). Administered by gavage to F344/N rats and B6C3F1 mice.美国国家毒理学计划(NTP)关于甲基丙烯腈(化学物质登记号:126 - 98 - 7)毒性研究的技术报告。通过灌胃方式给予F344/N大鼠和B6C3F1小鼠。
Toxic Rep Ser. 2000 May(47):1-56, A1-E6.
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[Relationship between the levels of endogenous thiols and lipid antioxidant activity and the radiosensitivity of different species of animals].[内源性硫醇水平、脂质抗氧化活性与不同种属动物放射敏感性之间的关系]
Radiobiologiia. 1978 Sep-Oct;18(5):655-60.
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Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxide.体内暴露于丙烯腈、苯乙烯或一氧化二丁烯后小鼠的姐妹染色单体交换和染色体畸变分析。
Environ Mutagen. 1986;8(3):439-48. doi: 10.1002/em.2860080312.
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Aflatoxin-albumin adducts: a basis for comparative carcinogenesis between animals and humans.黄曲霉毒素-白蛋白加合物:动物与人类之间比较致癌作用的基础。
Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):179-89.
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Influence of simultaneous exposure to acrylonitrile and styrene on the toxicity and metabolism of styrene in rats.同时暴露于丙烯腈和苯乙烯对大鼠体内苯乙烯毒性及代谢的影响。
Toxicol Appl Pharmacol. 1984 Sep 15;75(2):346-9. doi: 10.1016/0041-008x(84)90217-5.
10
Species differences in biliary excretion of methylmercury--role of non-protein sulfhydryls in bile.
Res Commun Chem Pathol Pharmacol. 1988 Nov;62(2):339-51.

引用本文的文献

1
Modulation of acrylonitrile-induced embryotoxicity in vitro by glutathione depletion.谷胱甘肽耗竭对体外丙烯腈诱导胚胎毒性的调节作用。
Arch Toxicol. 1993;67(3):164-72. doi: 10.1007/BF01973303.
2
Effects of single and repeated exposures to thermo-oxidative degradation products of poly(acrylonitrile-butadiene-styrene) (ABS) on rat lung, liver, kidney, and brain.单次及重复暴露于聚(丙烯腈-丁二烯-苯乙烯)(ABS)热氧化降解产物对大鼠肺、肝、肾和脑的影响。
Arch Toxicol. 1980 Dec;46(3-4):295-304. doi: 10.1007/BF00310447.
3
Hepatic content of free sulfhydryl compounds in animals exposed to vinyl acetate.
暴露于醋酸乙烯酯的动物肝脏中游离巯基化合物的含量。
Int Arch Occup Environ Health. 1982;51(2):185-9. doi: 10.1007/BF00378162.
4
In vivo biotransformation and biliary excretion of 1-14C-acrylonitrile in rats.大鼠体内1-¹⁴C-丙烯腈的生物转化及胆汁排泄
Arch Toxicol. 1982 Jul;50(2):175-85. doi: 10.1007/BF00373400.