Holub I, Tarkowski S
Int Arch Occup Environ Health. 1982;51(2):185-9. doi: 10.1007/BF00378162.
The content of free non-protein thiols (-SH) was investigated in the livers of guinea pigs, rats and mice after intraperitoneal injection of vinyl acetate (VA). A rapid change of the hepatic -SH level was found in guinea pigs after injection of 500 mg/kg VA. This resulted in a 50% decrease in -SH content. In mice the decrease was slower and amounted to only 23% four hours after injection of 300 mg/kg VA. Rats responded to a single dose of 450 mg/kg VA with only a 10% reduction of the -SH content of the liver. An approximately 20% decrease was observed after chronic intermittent exposure (5 h d-1 for 6 months) to 10, 100 or 500 mg/m3 VA.
在豚鼠、大鼠和小鼠腹腔注射醋酸乙烯酯（VA）后，对其肝脏中游离非蛋白硫醇（-SH）的含量进行了研究。注射500mg/kg VA后，豚鼠肝脏中的-SH水平迅速变化，导致-SH含量降低50%。在小鼠中，注射300mg/kg VA 4小时后，降低速度较慢，仅为23%。大鼠对450mg/kg VA的单次剂量反应，肝脏中-SH含量仅降低10%。在慢性间歇性暴露（每天5小时，持续6个月）于10、100或500mg/m³ VA后，观察到约20%的降低。
