系统性硬化症中的舒张功能异常：心脏功能储备相关缺陷的证据
Diastolic abnormalities in systemic sclerosis: evidence for associated defective cardiac functional reserve.
作者信息
Valentini G, Vitale D F, Giunta A, Maione S, Gerundo G, Arnese M, Tirri E, Pelaggi N, Giacummo A, Tirri G, Condorelli M
机构信息
Institute of Clinical Medicine, Division of Rheumatology, Second University of Naples, Italy.
出版信息
Ann Rheum Dis. 1996 Jul;55(7):455-60. doi: 10.1136/ard.55.7.455.
OBJECTIVE
To investigate the pattern of diastolic abnormalities in patients with systemic sclerosis (SSc) and the relationship between impaired ventricular filling and systolic function.
METHODS
Twenty four patients with SSc underwent M-mode and two dimensional echocardiography using echo-Doppler and gated blood pool cardiac angiography, both at rest and after exercise.
RESULTS
An impaired diastolic relaxation of the left ventricle was detected in 10 of the 24 patients with SSc. Left ventricular ejection fraction at rest in these 10 patients with impaired ventricular filling did not differ from that in the remaining 14 patients, but eight of the 10 failed to increase their ejection fraction during exercise, compared with two of the 14 with normal ventricular filling (p = 0.003).
CONCLUSION
Impaired relaxation of the left ventricle is a recently described feature of scleroderma heart disease. Diastolic dysfunction in SSc could depend on myocardial fibrosis or myocardial ischaemia, or both. It was found to be associated with a defective cardiac functional reserve. However, its prognostic significance remains to be clarified.
目的
研究系统性硬化症（SSc）患者舒张功能异常的模式以及心室充盈受损与收缩功能之间的关系。
方法
24例SSc患者在静息和运动后均接受了M型和二维超声心动图检查，采用回声多普勒和门控血池心脏血管造影术。
结果
24例SSc患者中有10例检测到左心室舒张松弛受损。这10例心室充盈受损患者的静息左心室射血分数与其余14例患者无差异，但10例中有8例在运动期间射血分数未增加，而14例心室充盈正常者中有2例（p = 0.003）。
结论
左心室舒张松弛受损是硬皮病性心脏病最近描述的一个特征。SSc中的舒张功能障碍可能取决于心肌纤维化或心肌缺血，或两者皆有。发现其与心脏功能储备缺陷有关。然而，其预后意义仍有待阐明。
Zotero 插件