Athanasiou S, Bourne T H, Khalid A, Okokon E V, Crayford T J, Hagström H G, Campbell S, Collins W P
King's College School of Medicine and Dentistry, London, United Kingdom.
Fertil Steril. 1996 Mar;65(3):556-60.
To assess the effect of indomethacin (taken at defined times) on follicular rupture, indexes of intrafollicular blood flow, and steroidogenesis.
Six healthy volunteers awaiting treatment for infertility by IVF-ET during subsequent natural cycles.
All women were examined (at least every 8 hours) by transvaginal ultrasonography with color Doppler imaging and had samples of blood taken for hormone analysis. A self-test for urinary LH was performed before each scan. Indomethacin was first taken (50 mg three times per day) according to the maximum follicular diameter (first four women) or when the LH dipstick gave a positive result; the drug was taken for > or = 3 days.
Follicular rupture was delayed in five of six cases (by 2 to 12 days). There was a reduction in intrafollicular peak systolic velocity before and after the positive urinary LH test compared with historical controls. Three follicles (50% of women) with the highest peak systolic velocity had an hemorrhagic appearance and persisted longer. There was no significant effect on menstrual cycle length or the levels of circulating FSH, E2, LH, or P.
Indomethacin administered at the time of a positive self-test for urinary LH can delay follicular rupture with an associated reduction in intrafollicular blood flow but with no apparent effects on hormonal or menstrual status.
评估吲哚美辛（在特定时间服用）对卵泡破裂、卵泡内血流指标及类固醇生成的影响。
6名健康志愿者，在随后的自然周期中等待通过体外受精-胚胎移植（IVF-ET）治疗不孕症。
所有女性均接受经阴道超声检查（至少每8小时一次）并进行彩色多普勒成像，同时采集血样进行激素分析。每次扫描前进行尿促黄体生成素（LH）自检。根据最大卵泡直径（前4名女性）或LH试纸呈阳性结果时开始首次服用吲哚美辛（每日3次，每次50mg）；药物服用≥3天。
6例中有5例卵泡破裂延迟（延迟2至12天）。与历史对照相比，尿LH检测呈阳性前后卵泡内收缩期峰值流速降低。3个收缩期峰值流速最高的卵泡（占女性的50%）出现出血表现且持续时间更长。对月经周期长度或循环中的促卵泡生成素（FSH）、雌二醇（E2）、LH或孕酮（P）水平无显著影响。
在尿LH自检呈阳性时服用吲哚美辛可延迟卵泡破裂，并伴有卵泡内血流减少，但对激素或月经状态无明显影响。
