Surbek D, Koller A, Pavic N
University Hospital, Basel, Switzerland.
Fertil Steril. 1996 Mar;65(3):670-2. doi: 10.1016/s0015-0282(16)58175-8.
To describe infertility treatment and pregnancy outcome in a patient with transfusion-dependent beta-thalassemia major and hypopituitarism.
Case report.
University-affiliated infertility clinic.
Twenty-four-year-old infertile patient with homozygous beta-thalassemia.
Co-treatment with GH and gonadotropins.
Ovulation induction with clomiphene citrate or gonadotropins alone was unsuccessful. Combined treatment with hMG, hCG, and recombinant human GH followed by intrauterine insemination resulted in a viable twin pregnancy.
Human GH as an adjunct to hMG and hCG seems to be a sensible approach in the treatment of infertile homozygous beta-thalassemic patients among which very few pregnancies are reported.
