Lindstrom S, Sugita S, Endo A, Ishida M, Huang P, Xi S H, Nerome K
Department of Virology I, National Institute of Health, Tokyo, Japan.
Arch Virol. 1996;141(7):1349-55. doi: 10.1007/BF01718836.
Recent human H3N2 influenza viruses isolated in Japan and China were characterised from an evolutionary point of view. They appeared to have divided into three minor branch clusters, including 1992-1993, 1993-1994 and 1994-1995 isolates. It was of particular interest to reveal that in addition to amino acid substitutions in the antigenic sites of the HA molecule, amino acid changes occurred at position 226 of the receptor binding site from lysine or glutamine to isoleucine in all strains belonging to the 1994-1995 branch cluster. This is the first evidence of human H3N2 influenza isolates, or any other influenza HA serotypes, to contain a conserved amino acid residue other than lysine or glutamine at this key position.
从进化的角度对近期在日本和中国分离出的人类H3N2流感病毒进行了特征分析。它们似乎已分为三个小分支簇，包括1992 - 1993年、1993 - 1994年和1994 - 1995年的分离株。特别值得注意的是，除了HA分子抗原位点的氨基酸替换外，在1994 - 1995分支簇的所有毒株中，受体结合位点第226位的氨基酸从赖氨酸或谷氨酰胺变为异亮氨酸。这是人类H3N2流感分离株或任何其他流感HA血清型在这个关键位置含有赖氨酸或谷氨酰胺以外的保守氨基酸残基的首个证据。
