Abraham E
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, USA.
New Horiz. 1996 May;4(2):184-93.
Transcriptional factors which bind to the promoter regions of genes play an important role in regulating gene expression. The transcription of immunoregulatory and proinflammatory cytokines as well as other proteins known to be important in producing organ system injury after trauma, blood loss, or sepsis is controlled both by the activation of transcriptional regulatory factors and by the interactions of these transcriptional factors with each other, resulting in augmentation or suppression of gene transcription. Most of the transcriptional factors which appear to play a role in modulating immune response in the setting of critical illness can be activated through several different pathways, often involving intracellular redox state and cytokine or endotoxin interaction with membrane receptors. In the severely injured patient, many of these activating mechanisms appear to be operative. Modulation of gene transcription, particularly in those organ systems (e.g., the lungs) which are most vulnerable to inflammatory injury, may be an important therapeutic target in critically ill patients.
与基因启动子区域结合的转录因子在调节基因表达中起重要作用。免疫调节和促炎细胞因子以及其他已知在创伤、失血或脓毒症后导致器官系统损伤中起重要作用的蛋白质的转录，既受转录调节因子的激活控制，也受这些转录因子相互作用的控制，从而导致基因转录的增强或抑制。大多数似乎在危重病情况下调节免疫反应中起作用的转录因子可通过几种不同途径激活，通常涉及细胞内氧化还原状态以及细胞因子或内毒素与膜受体的相互作用。在重伤患者中，许多这些激活机制似乎都在起作用。基因转录的调节，特别是在那些最易受炎症损伤的器官系统（如肺）中，可能是危重病患者的一个重要治疗靶点。
