Mendenhall W M, Parsons J T, Mancuso A A, Stringer S P, Cassisi N J
Department of Radiation Oncology, University of Florida Health Science Center, Gainesville 32610-0385, USA.
Head Neck. 1996 Jan-Feb;18(1):24-35. doi: 10.1002/(SICI)1097-0347(199601/02)18:1<24::AID-HED4>3.0.CO;2-0.
The purpose of this article is to present the results of radiotherapy with or without neck dissection for squamous cell carcinoma of the supraglottic larynx at the University of Florida and to compare these data with those obtained after conservation surgery.
Continuous-course radiotherapy alone or combined with a planned neck dissection was used to treat 209 patients with 211 supraglottic carcinomas between 1964 and 1992; all patients had follow-up for > or = 2 years.
The 5-year rates of local control after radiotherapy were as follows: T1, 100%; T2, 83%; T3, 68%; and T4, 56%. Tumor volume, as calculated on pretreatment computed tomography (CT) scan, and vocal cord mobility influenced the likelihood of local control.
Based on our data and the literature, early or moderately advanced supraglottic carcinomas may be treated successfully with either supraglottic laryngectomy or radiotherapy. Supraglottic laryngectomy probably produces a higher initial local control rate but, based on anatomic and coexisting medical constraints, is suitable for a smaller subset of patients and has a higher risk of complications compared with radiotherapy.
本文旨在介绍佛罗里达大学对声门上型喉鳞状细胞癌进行放疗联合或不联合颈部清扫术的结果，并将这些数据与保喉手术后获得的数据进行比较。
1964年至1992年间，采用单纯连续疗程放疗或联合计划性颈部清扫术治疗209例患者的211例声门上型癌；所有患者均随访≥2年。
放疗后5年局部控制率如下：T1期，100%；T2期，83%；T3期，68%；T4期，56%。根据治疗前计算机断层扫描（CT）计算的肿瘤体积和声带活动度影响局部控制的可能性。
根据我们的数据和文献，早期或中晚期声门上型癌可通过声门上喉切除术或放疗成功治疗。声门上喉切除术可能产生更高的初始局部控制率，但基于解剖学和并存的医学限制，适用于较小的患者亚组，且与放疗相比并发症风险更高。
