Ungkanont K, Byers R M, Weber R S, Callender D L, Wolf P F, Goepfert H
Department of Head and Neck Surgery, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Head Neck. 1996 Jan-Feb;18(1):60-6. doi: 10.1002/(SICI)1097-0347(199601/02)18:1<60::AID-HED8>3.0.CO;2-X.
Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor of the nasopharynx composed of fibrous connective tissue and an abundance of endothelium-lined vascular spaces. The name of the disease is derived from the fact that it occurs during adolescence, almost exclusively in boys.
This study examines the natural characteristics of JNA, the imaging techniques used to diagnose and stage the neoplasm, and the treatment approaches used to manage the disease.
Forty-three cases of JNA diagnosed and treated at the University of Texas M. D. Anderson Cancer Center over a 38-year period were reviewed for the study. The cases were divided into two groups, those occurring between 1955 and 1974 and those occurring between 1975 and 1991, to accurately represent the developments in diagnostic and treatment methodology during those time periods.
The results of our study show that: (1) the imaging techniques used after 1965 (angiography, computed tomography, and magnetic resonance imaging) greatly improve the staging of JNA; (2) morbidity, recurrence, and intraoperative complications decrease when preoperative embolization and skull-based surgical approaches are used; and (3) surgical resection is the most common primary treatment, with chemotherapy and radiotherapy recommended as possible other options.
青少年鼻咽血管纤维瘤（JNA）是一种鼻咽部的良性肿瘤，由纤维结缔组织和大量内衬内皮的血管间隙组成。该疾病的名称源于其发病于青春期，几乎仅见于男性这一事实。
本研究考察了JNA的自然特征、用于诊断和分期该肿瘤的成像技术以及用于治疗该疾病的方法。
对德克萨斯大学MD安德森癌症中心在38年期间诊断和治疗的43例JNA病例进行了回顾性研究。这些病例被分为两组，一组发生在1955年至1974年之间，另一组发生在1975年至1991年之间，以准确反映这两个时间段内诊断和治疗方法的发展情况。
我们的研究结果表明：（1）1965年之后使用的成像技术（血管造影、计算机断层扫描和磁共振成像）极大地改善了JNA的分期；（2）采用术前栓塞和颅底手术方法时，发病率、复发率和术中并发症会降低；（3）手术切除是最常见的主要治疗方法，化疗和放疗可作为其他可能的选择。
