Abe K, Miyakawa H, Miyachi K, Kako M, Furue H
Fourth Department of Internal Medicine, Teikyo University School of Medicine, Kawasaki.
Intern Med. 1995 Nov;34(11):1114-9. doi: 10.2169/internalmedicine.34.1114.
A 53-year-old man was admitted to our hospital for close examination of his liver. Serum hepatitis C virus (HCV) RNA and anti-liver/kidney microsome (LKM) 1 were positive. Benign monoclonal gammopathy and type I cryoglobulinemia (both of IgG lambda class) which are rarely seen in association with chronic hepatitis C, were found to be present. Interferon therapy was given, resulting in the disappearance of both HCV-RNA and type I cryoglobulin in the blood. We propose a hypothesis that the primary cause of anti-LKM-1-positive chronic hepatitis C is HCV infection which triggers secondary autoimmune phenomena presenting anti-LKM-1 and cryoglobulinemia.
一名53岁男性因肝脏的详细检查而入住我院。血清丙型肝炎病毒（HCV）RNA和抗肝肾微粒体（LKM）1呈阳性。发现存在与慢性丙型肝炎相关的罕见良性单克隆丙种球蛋白病和I型冷球蛋白血症（均为IgG λ类）。给予干扰素治疗后，血液中的HCV-RNA和I型冷球蛋白均消失。我们提出一个假说，即抗LKM-1阳性慢性丙型肝炎的主要原因是HCV感染，它引发了表现为抗LKM-1和冷球蛋白血症的继发性自身免疫现象。
