I型人类嗜T细胞病毒（HTLV-I）相关脊髓病/热带痉挛性截瘫伴急性型成人T细胞白血病。
Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis with acute type of adult T-cell leukemia.
作者信息
Furukawa Y, Okadome T, Tara M, Niina K, Izumo S, Osame M
机构信息
Third Department of Internal Medicine, Kagoshima University.
出版信息
Intern Med. 1995 Nov;34(11):1130-3. doi: 10.2169/internalmedicine.34.1130.
We report a 47-year-old Japanese woman with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) combined with acute type adult T-cell leukemia (ATL). The susceptibility for HAM/TSP and acute type of ATL is hitherto explained by human leukocyte antigen (HLA) haplotype-linked immune responsiveness to HTLV-I. This patient's HLA (A24Cw1B54DR4DQ4/A24Cw3B51DR8DQ1) included a HAM-associated HLA haplotype. This suggests that HAM patients with HAM-associated HLA haplotype can also develop the acute type of ATL.
我们报告了一名47岁的日本女性，她患有人类嗜T淋巴细胞病毒I型（HTLV-I）相关脊髓病/热带痉挛性截瘫（HAM/TSP），并合并急性型成人T细胞白血病（ATL）。迄今为止，HAM/TSP和急性型ATL的易感性是通过人类白细胞抗原（HLA）单倍型相关的对HTLV-I的免疫反应性来解释的。该患者的HLA（A24Cw1B54DR4DQ4/A24Cw3B51DR8DQ1）包含一个与HAM相关的HLA单倍型。这表明具有与HAM相关的HLA单倍型的HAM患者也可能发展为急性型ATL。
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