Darras V M, Cokelaere M, Dewil E, Arnouts S, Decuypere E, Kühn E R
Laboratory of Comparative Endocrinology, Zoological Institute, KULeuven, Belgium.
Gen Comp Endocrinol. 1995 Dec;100(3):334-8. doi: 10.1006/gcen.1995.1164.
The effects of a long term partial food restriction were studied in chickens and rats. In chickens the treatment resulted in increased plasma T4 levels while T4 levels in rats remained unchanged. Plasma T3 decreased in both species. In vitro hepatic outer ring deiodinating type I (ORD-I) activity was not influenced by the food restriction, suggesting that the amount of ORD-I enzyme present in the liver remained unchanged. In vitro hepatic inner ring deiodinating type III activity, on the contrary, was greatly increased in both species. This increase may contribute to the decreased circulating T3 levels by increasing the degradation of T3 and diverting the deiodination of T4 to rT3 instead of to T3.
在鸡和大鼠中研究了长期部分食物限制的影响。在鸡中，这种处理导致血浆T4水平升高，而大鼠的T4水平保持不变。两种动物的血浆T3均下降。食物限制并未影响体外肝脏外环Ⅰ型脱碘酶（ORD-I）的活性，这表明肝脏中ORD-I酶的量保持不变。相反，两种动物的体外肝脏内环Ⅲ型脱碘酶活性均大幅增加。这种增加可能通过增加T3的降解并将T4的脱碘作用转向rT3而非T3，从而导致循环T3水平降低。
