Rueckert P A, Slane P R, Lillis D L, Hanson P
Department of Medicine, University of Wisconsin Medical School, Madison 53792-3248, USA.
Med Sci Sports Exerc. 1996 Jan;28(1):24-32. doi: 10.1097/00005768-199601000-00010.
We investigated: 1) the mechanism of the hypotensive effect of a single bout of dynamic exercise in hypertensive subjects by measuring hemodynamic parameters before and for 2 h after treadmill exercise, and 2) the duration of the effect using ambulatory blood pressure (BP) monitoring once the subjects left the test site. Ten minutes after exercise there was a significant decrease from baseline systolic pressure (SP; -14 +/- 3 mm Hg), mean arterial pressure (MAP; -7 +/- 2 mm Hg), total peripheral resistance (TPR; -3.7 +/- 1.2 units), calf vascular resistance (CVR; -25.4 +/- 4.1 units), and an increase in HR (19 +/- 2 bpm). The changes in SP, DP, MAP, and HR were maintained during the 2 h of post-exercise monitoring; CVR remained decreased for 1 h; TPR returned to baseline within 20 min and then tended to be slightly elevated. CO was significantly decreased at 50, 60, and 120 min after exercise. We conclude that the early decline in BP after dynamic exercise in hypertensive subjects follows a biphasic pattern: 1) an initial decrease in total and regional vascular resistance with maintained CO, 2) followed by increasing resistance and decrease CO. Pre-exercise hypertensive BP values returned during subsequent ambulatory monitoring.
1）通过测量高血压受试者在跑步机运动前及运动后2小时的血流动力学参数，探究单次动态运动降压作用的机制；2）在受试者离开测试地点后，使用动态血压监测来确定该作用的持续时间。运动后10分钟，收缩压（SP；-14±3 mmHg）、平均动脉压（MAP；-7±2 mmHg）、总外周阻力（TPR；-3.7±1.2单位）、小腿血管阻力（CVR；-25.4±4.1单位）较基线水平显著下降，心率（HR）增加（19±2次/分钟）。运动后2小时监测期间，SP、舒张压（DP）、MAP和HR的变化持续存在；CVR在1小时内持续下降；TPR在20分钟内恢复至基线水平，随后有轻微升高趋势。运动后50、60和120分钟时，心输出量（CO）显著下降。我们得出结论，高血压受试者动态运动后血压早期下降呈双相模式：1）最初总外周阻力和局部血管阻力下降，CO保持不变；2）随后阻力增加，CO下降。运动前高血压血压值在随后的动态监测期间恢复。
