Mori S, Mitarai G, Takabayashi A, Usui S, Sakakibara M, Nagatomo M, von Baumgarten R J
Research Institute of Environmental Medicine, Nagoya University, Japan.
Aviat Space Environ Med. 1996 Mar;67(3):256-61.
Evidence in support of the sensory conflict hypothesis for space motion sickness (SMS) is still needed.
We hypothesized that sensory conflict and recovery processes should be demonstrated in intact fish during initial days of microgravity exposure, as a disturbance and restoration of the dorsal light response (DLR; a functional model of visual-graviceptor interaction), respectively. We also expected that this would be true in an otolith-removed fish if it had been fully compensated for dysfunction before the exposure.
The DLR of carp (Cyprinus carpio) was examined intermittently during the 8-d mission of Spacelab-J. Two carp, normal and labyrinthectomized (LB), made the flight.
In the normal carp, the DLR was unstable for the first 3 d inflight but gradually recovered thereafter. The recovery was characterized by gradual restoration of the DLR tilt speed. The LB fish whose otoliths had been removed 2 mo before the flight maintained DLR at the first inflight test session (22 h after launch), but DLR was disrupted at 2 d as in normal fish. The recovery process could not be evaluated in this fish, because the EEG cable which was attached to the fish for supplementary study became tightly twisted and thus immobilized the fish for the remainder of the experiment.
These findings provided additional evidence in fish for sensory-motor disorder and readjustment during the early phase of microgravity, thus supporting the sensory conflict hypothesis for SMS.
仍需支持空间运动病（SMS）感觉冲突假说的证据。
我们假设，在微重力暴露的最初几天，完整的鱼类应表现出感觉冲突和恢复过程，分别作为背侧光反应（DLR；视觉 - 重力感受器相互作用的功能模型）的干扰和恢复。我们还预期，如果在暴露前已对耳石移除的鱼类进行了功能障碍的完全补偿，情况也会如此。
在空间实验室 - J的8天任务期间，间歇性地检查鲤鱼（Cyprinus carpio）的DLR。两条鲤鱼，正常鱼和迷路切除（LB）鱼参与了飞行。
在正常鲤鱼中，DLR在飞行的前3天不稳定，但此后逐渐恢复。恢复的特征是DLR倾斜速度逐渐恢复。飞行前2个月已移除耳石的LB鱼在首次飞行测试期间（发射后22小时）保持DLR，但与正常鱼一样，DLR在2天时受到干扰。由于用于补充研究而连接到鱼身上的脑电图电缆严重扭曲，使鱼在实验的剩余时间内无法活动，因此无法评估这条鱼的恢复过程。
这些发现为鱼类在微重力早期阶段的感觉运动障碍和重新调整提供了额外证据，从而支持了SMS的感觉冲突假说。
