脂肪酸及其前列腺素衍生物：主动脉平滑肌细胞增殖的抑制剂。
Fatty acids and their prostaglandin derivatives: inhibitors of proliferation in aortic smooth muscle cells.
作者信息
Huttner J J, Gwebu E T, Panganamala R V, Milo G E, Cornwell D C, Sharma H M, Geer J C
出版信息
Science. 1977 Jul 15;197(4300):289-91. doi: 10.1126/science.877555.
PMID:877555
Abstract
Prostaglandins are synthesized from eicosa-8,11,14-trienoic acid and eicosa-5,8,11-14-tetraenoic acid by smooth muscle cell cultures from guinea pig aorta. Production is inhibited by indomethacin. The precursor fatty acids and their prostaglandin derivatives inhibit proliferation of the cell cultures. The relative availability of fatty acids for prostaglandin biosynthesis may represent a control mechanism for cell proliferation.
摘要
前列腺素由豚鼠主动脉平滑肌细胞培养物从8,11,14-二十碳三烯酸和5,8,11,14-二十碳四烯酸合成。生产受到吲哚美辛的抑制。前体脂肪酸及其前列腺素衍生物抑制细胞培养物的增殖。前列腺素生物合成中脂肪酸的相对可用性可能代表细胞增殖的一种控制机制。
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