脂肪酸代谢与细胞增殖：IV. 环孢素A诱导内源性脂肪酸释放所产生的前列腺素生物合成的影响
Fatty acid metabolism and cell proliferation: IV. Effect of prostanoid biosynthesis from endogenous fatty acid release with cyclosporin-A.
作者信息
Lindsey J A, Morisaki N, Stitts J M, Zager R A, Cornwell D G
出版信息
Lipids. 1983 Aug;18(8):566-9. doi: 10.1007/BF02535399.
PMID:6413804
Abstract
Cyclosporin-A (Cyc-A) stimulates prostanoid (PGI2) synthesis in confluent smooth muscle cells from guinea pig aorta through the release of endogenous fatty acid. Cyc-A, like other stimulatory agents for prostanoids, promotes smooth muscle cell proliferation and prostanoid synthesis in these proliferating cells. Indomethacin, a cyclooxygenase inhibitor, and exogenous arachidonic acid block the Cyc-A effect on cell proliferation.
摘要
环孢菌素A（Cyc-A）通过释放内源性脂肪酸刺激豚鼠主动脉汇合平滑肌细胞中前列腺素（PGI2）的合成。与其他前列腺素刺激剂一样，Cyc-A促进这些增殖细胞中的平滑肌细胞增殖和前列腺素合成。环氧合酶抑制剂吲哚美辛和外源性花生四烯酸可阻断Cyc-A对细胞增殖的作用。
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