δ9-四氢大麻酚在体外对淋巴细胞膜酶的抑制作用。
Inhibition of a lymphocyte membrane enzyme by delta9-tetrahydrocannabinol in vitro.
作者信息
Greenberg J H, Saunders M E, Mellors A
出版信息
Science. 1977 Jul 29;197(4302):475-7. doi: 10.1126/science.877571.
PMID:877571
Abstract
Delta-9-tetrahydrocannabinol (delta9-THC) inhibited the activity of lysolecithin acyl transferase, a membrane-bound lymphocyte enzyme, at concentrations above 1.3 muM. Stimulation of acyl transferase activity by concanavalin A, an early response in lymphocyte activation, was entirely abolished in the presence of delta9-THC.
摘要
9-四氢大麻酚（delta9-THC）在浓度高于1.3微摩尔时可抑制溶血卵磷脂酰基转移酶（一种膜结合淋巴细胞酶）的活性。伴刀豆球蛋白A对酰基转移酶活性的刺激（淋巴细胞激活的早期反应）在存在delta9-THC的情况下完全被消除。
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