Buckley M, O'Morain C
Dept of Gastroenterology, Meath/Adelaide Hospitals, Dublin, Ireland.
Acta Gastroenterol Belg. 1995 Sep-Dec;58(5-6):382-7.
The presence of Helicobacter pylori is associated with approximately an 8 fold increase risk of developing gastric cancer. Helicobacter pylori is easy to diagnose non-invasively and effectively treated with antibiotics. More research into the natural history of Helicobacter pylori associated premalignant lesions, e.g. the reversibility of types 1 and 2 intestinal metaplasia, is necessary before a screening strategy can be developed. It also remains to be seen whether specific strains of H. pylori are associated with gastric cancer and whether differences in the host response to Helicobacter pylori infection affect the clinical outcome. When these issues are clarified it will be possible to identify individuals who are at high risk of developing gastric cancer and who will benefit from eradication. It is inevitable that asymptomatic individuals at high risk will be screened for the presence of Helicobacter pylori infection.
幽门螺杆菌的存在与患胃癌的风险增加约8倍有关。幽门螺杆菌易于通过非侵入性方法诊断，并用抗生素有效治疗。在制定筛查策略之前，有必要对幽门螺杆菌相关癌前病变的自然史进行更多研究，例如1型和2型肠化生的可逆性。幽门螺杆菌的特定菌株是否与胃癌有关，以及宿主对幽门螺杆菌感染的反应差异是否会影响临床结果，仍有待观察。当这些问题得到澄清后，就有可能识别出患胃癌风险高且将从根除治疗中受益的个体。对无症状的高危个体进行幽门螺杆菌感染筛查将是不可避免的。
