Lauer M, Heinsen H
Department of Psychiatry, University of Würzburg.
J Hirnforsch. 1996;37(2):243-54.
More than 400 publications per year deal with the Nucleus accumbens, however its morphological substrate and anatomical borders appear arbitrary. With a modified Nissi-technique applied to complete sets of thick serial, frontoparallel sections, it became possible to characterize the human Nucleus accumbens. In two series a clear delineation of its borders is documented. Along its rostro-caudal axis, the Nucleus accumbens shows morphological differences: the rostral Nucleus accumbens exhibits a higher cell-density and basophilia than Nucleus caudatus and Putamen; in caudal planes, the Nucleus accumbens dissolves into cell-clusters. A hitherto unrecognized supracommissural part of the Nucleus accumbens dorsal to the Commissura anterior is contiguous to the medial and lateral parts of the Nucleus interstitialis striae terminalis. The thickness of the hemispheric slices (approximately 600 micrometers) facilitated the topographical unravelling of the surrounding cell-islands. In accordance with Sanides (1957) these islands were referred to as Insulae terminales. Based on their topography and cellular structure, they were termed insulae terminales subputaminales (ltsp), Insulae terminales nuclei accumbentis (Itna), Insulae terminales supracommissurales (Itsc) and Insulae terminales olfactoriae mediales et laterales (Itom, Itol). The Insulae terminales form an almost complete envelope around the human Nucleus accumbens and could correspond to the neurochemically defined accumbal shell-region of the rat. Marked differences between medial and lateral insulae terminales olfactoriae permit a clear delineation between the human Nucleus accumbens and the lateral, rudimentary Tuberculum olfactorium: the basis for modifying the concept of a ventral striatum in man.
每年有超过400篇出版物涉及伏隔核，然而其形态学基质和解剖边界似乎是随意的。通过将改良的尼氏技术应用于完整的厚连续额平行切片组，得以对人类伏隔核进行特征描述。在两个系列中记录了其边界的清晰界定。沿着其前后轴，伏隔核呈现出形态学差异：伏隔核前部的细胞密度和嗜碱性高于尾状核和壳核；在后部平面，伏隔核溶解为细胞簇。在室间连合前方、伏隔核背侧的一个迄今未被认识的连合上部分与终纹床核的内侧和外侧部分相邻。半球切片的厚度（约600微米）有助于对周围细胞岛进行地形学解析。根据萨尼德斯（1957年）的研究，这些岛被称为终纹岛。根据它们的地形和细胞结构，它们被命名为壳核下终纹岛（ltsp）、伏隔核终纹岛（Itna）、连合上终纹岛（Itsc）以及内侧和外侧嗅觉终纹岛（Itom，Itol）。终纹岛在人类伏隔核周围形成了一个几乎完整的包膜，可能对应于大鼠神经化学定义的伏隔核壳区。内侧和外侧嗅觉终纹岛之间的显著差异使得能够清晰地区分人类伏隔核和外侧的、发育不全的嗅结节：这是修改人类腹侧纹状体概念的基础。
