Hartz-Schütt C G, Mai J K
Zentrum für Anatomie und Hirnforschung, Abteilung für Neuroanatomie Heinrich-Heine-Universität, Düsseldorf, FR Germany.
J Hirnforsch. 1991;32(3):317-42.
The distribution pattern of cholinesterase activity in the basal forebrain region was examined in five human brains without any history of neurologic or psychiatric disorders. Complete sets of serial sections allowed a three-dimensional reconstruction of this region. The intensity grading and the distribution pattern of the specific and non-specific cholinesterase activity was depicted diagramatically. The distribution pattern of cholinesterase activity in the supracommissural striatum demonstrated the well-known striosomal configuration, particularly in the head of the caudate nucleus. Within this nucleus caudatus the striosomes appeared connected with a subventricular zone of low acetylcholinesterase-activity. Bands of very high activity could be demonstrated from the dorsolateral and ventral areas of the caudate nucleus to the lateral border of the putamen and the commissural and subcommissural division of the ventral striatum. The distribution pattern of cholinesterase activity in the subcommissural region showed very close correlation to the cytomorphological subdivisions of the striatum as defined by Brockhaus (1942). In addition to his topographic description it was possible to define the tuberculum olfactorium and several subdivisions of the interstitial nucleus of the stria terminalis. The inhibition of non-specific esterase activity by ISO-OMPA in the globus pallidus allowed distinction between striatal and pallidal components. Three-dimensional reconstructions of the terminal islands revealed several types, which were named according to their topography as insulae substriatales, -subventriculares, -olfactoriae, -magnae, and -interstitiales. Characteristically, the core of these islands consisted of clusters of tightly packed, extremely high acetylcholinesterase-positive cells. Cholinesterase activity of the surrounding rim region ranged from negative to strongly positive depending on the position and type of the island. The findings suggest that the islands represent derivatives of the fundus striati region as defined by Brockhaus and are connected to the dorsal striatum by means of cellular bridges.
在五例无神经或精神疾病史的人类大脑中，研究了基底前脑区域胆碱酯酶活性的分布模式。完整的连续切片系列实现了该区域的三维重建。以图表形式描绘了特异性和非特异性胆碱酯酶活性的强度分级及分布模式。联合上纹状体中胆碱酯酶活性的分布模式显示出众所周知的纹状体小体结构，尤其是在尾状核头部。在尾状核内，纹状体小体似乎与乙酰胆碱酯酶活性较低的室下区相连。从尾状核的背外侧和腹侧区域到壳核的外侧边界以及腹侧纹状体的联合和联合下部分，可以显示出非常高活性的条带。联合下区域胆碱酯酶活性的分布模式与布罗克豪斯（1942年）定义的纹状体细胞形态学细分密切相关。除了他的地形学描述外，还可以确定嗅结节和终纹床核的几个细分。在苍白球中，ISO - OMPA对非特异性酯酶活性的抑制作用使得能够区分纹状体和苍白球成分。终末岛的三维重建显示出几种类型，根据其地形学特征分别命名为纹状体下岛、室下岛、嗅岛、大岛和间质岛。其特征是，这些岛的核心由紧密堆积的、乙酰胆碱酯酶阳性的极高细胞簇组成。根据岛的位置和类型，周围边缘区域的胆碱酯酶活性从阴性到强阳性不等。研究结果表明，这些岛代表了布罗克豪斯所定义的纹状体底部区域的衍生物，并通过细胞桥与背侧纹状体相连。
