Nesi G, Vezzosi V, Amorosi A, Menghetti I, Selli C
Department of Pathology, University of Florence, Italy.
Urol Int. 1996;56(4):250-3. doi: 10.1159/000282853.
A paraganglioma of the urinary bladder in a 60-year-old woman presented with irritative voiding symptoms, without hematuria or hypertension. Sonography revealed a well-limited ovoid mass of the posterior wall, and cystoscopy showed that it was covered by normally appearing mucosa. Treatment consisted of transurethral resection, and the patient has been followed for 2 years without recurrence. Histologically the lesion consisted of small nests of spindle cells with clear to acidophilic cytoplasm; mitotic activity was inconspicuous. Immunohistochemical analyses revealed that the tumor cells were strongly positive for neuron-specific enolase and chromogranin A, and negative for cytokeratin, vimentin, neurofilaments, glial fibrillary acid protein and HMB 45. Sustentacular cells at the periphery of neoplastic cell clusters were positive for S-100 protein.
一名60岁女性膀胱副神经节瘤表现为刺激性排尿症状，无血尿或高血压。超声检查显示后壁有一个边界清晰的卵圆形肿块，膀胱镜检查显示其被外观正常的黏膜覆盖。治疗方法为经尿道切除术，该患者已随访2年无复发。组织学上，病变由小巢状梭形细胞组成，细胞质透明至嗜酸性；有丝分裂活性不明显。免疫组织化学分析显示，肿瘤细胞神经元特异性烯醇化酶和嗜铬粒蛋白A呈强阳性，细胞角蛋白、波形蛋白、神经丝、胶质纤维酸性蛋白和HMB 45呈阴性。肿瘤细胞簇周边的支持细胞S-100蛋白呈阳性。
