Roles of protein-tyrosine phosphatases in growth factor signalling.

Protein-tyrosine phosphatases (PTPs) as well as protein-tyrosine kinases play key roles in various growth factor-or cytokine-mediated signal transduction pathways. Some PTP directly dephosphorylates tyrosine-phosphorylated growth factor receptors, whereas others mediate upstream signals to the downstream pathway as a second messenger of growth factor stimulus. In addition, some PTP functions as a negative feed-back signal in the growth-factor signalling. Since PTPs appear to regulate growth factor-mediated cell proliferation in both a positive and negative manner, overexpression or loss of certain types of PTPs might contribute to malignant transformation of cells.