Scott P H, Peacock A J
Department of Respiratory Medicine, Western Infirmary, Glasgow, UK.
Thorax. 1996 Aug;51(8):864-6. doi: 10.1136/thx.51.8.864.
Pulmonary hypertension is associated with pulmonary vascular remodelling, rendering the vessels unresponsive to vasodilators. An understanding of the mechanisms which cause this remodelling is required, which is likely to be linked to changes in vascular tone whether stimulated by hypoxia or other factors. One way to approach this is to try to understand the intracellular signalling pathways associated with hypoxia in pulmonary artery cells. This understanding could provide opportunities for therapeutic intervention using agents which will interfere with the signalling systems.
肺动脉高压与肺血管重塑相关，使血管对血管扩张剂无反应。需要了解导致这种重塑的机制，这可能与血管张力的变化有关，无论这种变化是由缺氧还是其他因素刺激引起的。解决这个问题的一种方法是尝试了解肺动脉细胞中与缺氧相关的细胞内信号通路。这种了解可以为使用干扰信号系统的药物进行治疗干预提供机会。
