A novel cDNA isolated from the mouse eye lens encoding a protein with zinc fingers and a KRAB domain.
作者信息
Brady J P, Piatigorsky J
机构信息
Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2730, USA.
出版信息
DNA Seq. 1995;5(6):389-92. doi: 10.3109/10425179509020871.
PMID:8777319
Abstract
A cDNA clone, pMLZ-8, was isolated from a newborn mouse eye lens cDNA library using a consensus zinc finger oligonucleotide hybridization probe. The cDNA contains an open reading frame that conceptually encodes a 606 amino acid protein. The protein possesses a "KRAB" domain at its amino-terminus and has a carboxy-terminal region with fifteen consensus C2H2 zinc fingers. PCR analysis reveals the presence of pMLZ-8 mRNA in lens, liver, kidney, spleen, and brain of newborn mice.
摘要
Zotero 插件