分离出一个编码具有LeR和KRAB-A结构域的广泛表达的新型锌指蛋白的cDNA。
Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains.
作者信息
Yokoyama M, Nakamura M, Okubo K, Matsubara K, Nishi Y, Matsumoto T, Fukushima A
机构信息
Pharmaceutical Basic Research Laboratories (Aobadai) Japan Tobacco, Inc., Yokohama, Kanagawa.
出版信息
Biochim Biophys Acta. 1997 Jul 17;1353(1):13-7. doi: 10.1016/s0167-4781(97)00074-2.
We have isolated a human cDNA clone representing a novel human gene. The predicted 683-amino-acid protein, designated FPM315, contains nine C2H2-type zinc finger motifs and two regions homologous to the LeR domain, a finger-associated structural domain, and the A element of the Kruppel-associated box (KRAB) domain involved in transcriptional repression. The FPM315 mRNAs were expressed in all human tissues so far examined. A cross-species genomic hybridization indicates that the FPM315 gene is highly conserved among eukaryotes. These data suggest that FPM315 might play an important role in basic cellular processes.
我们分离出了一个代表新人类基因的人类cDNA克隆。预测的683个氨基酸的蛋白质，命名为FPM315，包含九个C2H2型锌指基序以及两个与LeR结构域、一个与指相关的结构域和参与转录抑制的Kruppel相关框（KRAB）结构域的A元件同源的区域。FPM315 mRNA在迄今为止检测的所有人类组织中均有表达。种间基因组杂交表明FPM315基因在真核生物中高度保守。这些数据表明FPM315可能在基本细胞过程中发挥重要作用。
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