Descotes J L, Payen E, Rambeaud J J, Peuridieu J F, Baudot A, Odin J, Mazuer J, Boutron P, Delon-Martin C, Dupeyre R
Service d'Urologie et de transplantation rńale, CHU de Grenoble.
Prog Urol. 1995 Dec;5(6):927-31; discussion 931-2.
After discussing the problem of organ cryopreservation and reviewing the current data available on this subject, the Grenoble project is presented. Physical and biological studies have been combined with experimentation of autologous renal transplantation in rabbits to assess the functional value of the retransplanted organ after treatment and cooling. Renal resistances are measured during perfusion of the kidney with the cryoprotective solution. In order to verify the homogeneity of the cryoprotector concentration in the organ, on NMR spectral imaging test has been developed. A new rapid imaging method now allows real time monitoring of concentration variations during perfusion. In addition to concentration and homogeneity, analysis of local spectra also provides information about the local temperature de the kidney.
在讨论了器官冷冻保存问题并回顾了该主题的现有数据后，介绍了格勒诺布尔项目。物理和生物学研究与兔自体肾移植实验相结合，以评估处理和冷却后再移植器官的功能价值。在用冷冻保护溶液灌注肾脏期间测量肾阻力。为了验证器官中冷冻保护剂浓度的均匀性，开发了一种核磁共振光谱成像测试。一种新的快速成像方法现在可以实时监测灌注期间的浓度变化。除了浓度和均匀性外，局部光谱分析还提供了有关肾脏局部温度的信息。
