Bagirov A M
Urol Nefrol (Mosk). 1998 Jul-Aug(4):29-32.
In cadaveric renal transplantation with simple cold storage, pretransplant evaluation of allograft viability creates an important problem. To assess the degree of ischemic damage and microcirculation of the renal allograft, experiment comparing parameters, like median perfusate flow and median intrarenal resistance, with histological findings was made. Kidney harvesting was performed from three groups of New Zealand rabbits by keeping warm ischemic time zero, thirty, sixty minutes for each group. Following perfusion with Euro-Collins solution and 24 and 48 hours of hypothermic preservation, perfusion was repeated. Perfusion parameters were measured and histopathological examination of the kidneys was made with light microscopy. In arterioles and glomerular, peritubular capillaries, red blood cell trapping was seen. It was also observed that an increase of warm ischemic time aggravates the erythrocyte aggregation and tubular degeneration. Following reperfusion, resistance measured from renal arteries by Protocol Propaq 106 manometer was named as terminal intrarenal resistance. It is noticeable that this simply measured parameter shows correlation with other parameters and histopathological findings.
在单纯冷藏的尸体肾移植中，移植前评估同种异体肾的活力是一个重要问题。为了评估肾移植的缺血损伤程度和微循环，进行了实验，将灌注液流量中位数和肾内阻力中位数等参数与组织学结果进行比较。通过使每组的热缺血时间分别为零、三十、六十分钟，从三组新西兰兔身上摘取肾脏。在用欧洲柯林斯溶液灌注并进行24小时和48小时低温保存后，再次进行灌注。测量灌注参数，并使用光学显微镜对肾脏进行组织病理学检查。在小动脉、肾小球、肾小管周围毛细血管中可见红细胞滞留。还观察到热缺血时间的增加会加重红细胞聚集和肾小管变性。再灌注后，使用Protocol Propaq 106压力计从肾动脉测量的阻力被命名为终末期肾内阻力。值得注意的是，这个简单测量的参数与其他参数和组织病理学结果具有相关性。
