Mibashan R S, Rodeck C H, Thumpston J K, Edwards R J, Singer J D, White J M, Campbell S
Lancet. 1979 Jun 23;1(8130):1309-11. doi: 10.1016/s0140-6736(79)91946-9.
Fetal blood unmixed with maternal blood or amniotic fluid was obtained by direct-vision fetoscopy in 22 consecutive cases at 15--22 weeks' gestation; the investigation was done either for prenatal diagnosis or before therapeutic abortion. Fetal plasma factors VIIIC and IX averaged 50 I.U./dl (S.D. 12.8) and 12.5 I.U./dl (S.D. 2.4), respectively. Two male fetuses at risk of haemophilia had normal factor VIIIC levels by these criteria, and both pregnancies ended in the birth of a normal boy. Five others gave 3 normal and 2 haemophilic results, which were confirmed in two of the three terminated pregnancies.
在妊娠15 - 22周的22例连续病例中，通过直视胎儿镜获取未与母体血液或羊水混合的胎儿血液；该研究是为了进行产前诊断或在治疗性流产前进行。胎儿血浆因子VIIIC和IX的平均水平分别为50国际单位/分升（标准差12.8）和12.5国际单位/分升（标准差2.4）。根据这些标准，两名有血友病风险的男性胎儿的因子VIIIC水平正常，且两次妊娠均以正常男婴出生告终。另外五例中，有3例结果正常，2例为血友病结果，在3例终止妊娠的病例中有2例得到证实。
