Suárez Ortega S, Rodríguez Perdomo E, Parrilla Díaz J, Ayala Galán E, Artiles Vizcaíno J, Melado Sánchez P
Servicio de Medicina Interna, Complejo Hospitalario Las Palmas Norte, Las Palmas de Gran Canaria.
Arch Bronconeumol. 1995 Aug-Sep;31(7):368-70.
A 73-year-old man was admitted to our hospital after convulsive seizures preceded by encephalopathy lasting one week. He had a history of long-standing chronic obstructive pulmonary disease and analysis showed hypokalemia, respiratory alkalosis and toxic levels of theophylline. We discuss the severity of the convulsions and arrhythmias, the high incidence of hypokalemia in theophylline poisoning, as well as the role of hypokalemia in the pathogenesis of the convulsions and the high level of mortality in this type of intoxication. Other possible mechanisms involved in theophylline encephalopathy are mentioned, along with the controversial use of theophylline for continuous treatment of chronic obstructive pulmonary disease.
一名73岁男性在出现持续一周的脑病后发生惊厥性癫痫发作，随后被收治入我院。他有长期慢性阻塞性肺疾病史，检查显示低钾血症、呼吸性碱中毒以及茶碱中毒水平。我们讨论了惊厥和心律失常的严重程度、茶碱中毒时低钾血症的高发生率，以及低钾血症在惊厥发病机制中的作用和此类中毒的高死亡率。文中还提及了茶碱性脑病涉及的其他可能机制，以及茶碱用于慢性阻塞性肺疾病持续治疗存在的争议。
