Sekizawa K, Aikawa T, Yanai M, Itabashi S, Fukushima T, Sasaki H
Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai.
Tohoku J Exp Med. 1990 Dec;162(4):303-7. doi: 10.1620/tjem.162.303.
Two aged patients with bronchial asthma and chronic obstructive pulmonary disease who suffered convulsions that resulted in permanent brain damage during treatment with the recommended therapeutic dose of theophylline are presented here. A dose or concentration of theophylline lower than the recommended one should be considered in the treatment of some aged patients with pulmonary obstructive disease.
本文报告了两名患有支气管哮喘和慢性阻塞性肺疾病的老年患者，他们在使用推荐治疗剂量的茶碱进行治疗期间发生惊厥，导致永久性脑损伤。在治疗一些患有肺部阻塞性疾病的老年患者时，应考虑使用低于推荐剂量或浓度的茶碱。
