Umenai T, Lee H W, Lee P W, Saito T, Toyoda T, Hongo M, Yoshinaga K, Nobunaga T, Horiuchi T, Ishida N
Lancet. 1979 Jun 23;1(8130):1314-6. doi: 10.1016/s0140-6736(79)91948-2.
In March, 1975, and January, 1978, there were outbreaks of Korean haemorrhagic fever (K.H.F.) among staff in the animal laboratory of the clinical research building of Tohoku University hospital. 13 doctors and 1 veterinarian had K.H.F., and all except 1 had a mild but typical clinical course. K.H.F. antibody titres were significantly raised in all 14 patients. 12 other doctors working in the same room had no symptoms and no K.H.F. antibody. K.H.F. antibody was also detected in 3 animal technicians who had not been ill, but who had worked in the same room. Antibody was not detected in any of the 4 technicians who worked in different animal rooms in another building. Epidemiological studies suggest that laboratory rats were the source of the infection. High titres of K.H.F. antibody were most common in rats reared in the animal laboratory associated with the outbreak.
1975年3月和1978年1月，东北大学医院临床研究楼动物实验室的工作人员中爆发了韩国出血热（K.H.F.）。13名医生和1名兽医感染了K.H.F.，除1人外，所有人都经历了轻微但典型的临床病程。所有14名患者的K.H.F.抗体滴度均显著升高。在同一房间工作的另外12名医生没有症状，也没有K.H.F.抗体。在3名未患病但在同一房间工作的动物技术人员中也检测到了K.H.F.抗体。在另一栋楼不同动物房工作的4名技术人员中均未检测到抗体。流行病学研究表明，实验大鼠是感染源。在与疫情相关的动物实验室饲养的大鼠中，高滴度的K.H.F.抗体最为常见。
